Location: Lexington, United States; Boston, United States

Job reference: R-182910

Date posted: 10/19/2023

This is what you will do:

Alexion- Astrazeneca rare disease Genomics medicine department is seeking a highly motivated Co-op to join our gene therapy vector engineering and production group. This position will focus on designing sophisticated and efficient Adeno associate virus(AAV) vector tool for delivering therapeutic cassette, at the same time apply innovating vector production technologies to realize mass production. We offer 1:1 training in a variety of tasks involved in the AAV and gene therapy field and provide individuals a great opportunity to learn and grow in a dynamic team.

You will be responsible for:

• Manufactures research grade rAAV vectors using suspension cell culture in shaker flasks.
• Drives processes for purification of rAAV applying various techniques.
• Performs analytical tests such as qPCR, ddPCR for characterization of rAAV vectors, etc.
• Performs molecular cloning and giga prep for creating the constructs for vectorization.
• Fills out batch records, and accurately completes documentation associated with preclinical manufacturing.
• Monitors the plasmid supply and control the quality for plasmids.
• Provides technical support to early development when appropriate.
• Participate in project meetings and conduct work reports.

You will need to have:

• Hands-on experience in biology lab.
• Experience with adherent or suspension cell culture.
• Experience with PCR and qPCR
• Ability to work independently with confidence
• Strong verbal communications skills and ability to excel in a fast-paced environment

We would prefer for you to have:

• 1 year experience in the biology lab.
• AAV related biology knowledge
• Master’s degree
• Gene and cell therapy knowledge

Expectation of working in the office 4 days a week statement: When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working give us the platform we need to connect, work at pace and challenge perceptions. That’s why we work, on average, a minimum of four days per week from the office. But that doesn’t mean we’re not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.

AstraZeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law.

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