Voyager Therapeutics (Nasdaq: VYGR) is a biotechnology company dedicated to breaking through barriers in gene therapy and neurology. The potential of both disciplines has been constrained by delivery challenges; Voyager is leveraging cutting-edge expertise in capsid discovery and deep neuropharmacology capabilities to address these constraints. Voyager's TRACER™ AAV capsid discovery platform has generated novel capsids with high target delivery and blood-brain barrier penetration at low doses, potentially addressing the narrow therapeutic window associated with conventional gene therapy delivery vectors. This platform is fueling alliances with Pfizer Inc., Novartis Pharma AG, Neurocrine Biosciences, Inc., and Sangamo Therapeutics, Inc., as well as multiple programs in Voyager's own pipeline. Voyager's pipeline includes wholly owned and collaborative preclinical programs in Alzheimer's disease, amyotrophic lateral sclerosis (ALS), Parkinson's disease, and other diseases of the central nervous system, with a focus on validated targets and biomarkers to enable a path to rapid potential proof-of-biology. For more information, visit www.voyagertherapeutics.com.

Job Summary:

The qualified candidate will carry out upstream process development activities for the manufacture of

pre-clinical and cGMP grade rAAV products as independently as possible.

The ability to independently organize and design experiments, analyze data and report the results of their work in a concise and well documented manner are important aspects of the position.

Position Specific Responsibilities:

• Design, development, and optimization of cell growth, transfection, viral infection, and rAAV

manufacturing using shake flasks, small-scale and large-scale bioreactors.

• Assemble, sterilize, prepare, and maintain bioreactors, ancillary materials and equipment for cell

culture, viral infection, and harvest experiments

• Develop protocols for viral genome / capsid production in shake flasks, wave bioreactors and

stirred tank bioreactors

• Execute and develop assays to monitor cell growth, metabolite production, nutrient utilization as

well as monitor baculovirus infection and metabolic/physiological state of cells

• Develop and execute sample preparation protocols to enable assessment of AAV quality
• Generate and characterize host cell and viral (infected cell) banks
• Author experimental reports, SOPs, batch records, technology transfer documents and support

authoring of relevant regulatory documents

• Manage and maintain data as well as data analysis in an organized manner including timely

completion of ELN records

• Assist with and lead the production of nonclinical materials at Voyager
• Train colleagues with respect to lab activities

Support lab operations through longer term management of lab equipment and logistics; support

development of lab capabilities through analysis of lab operations and capital management. Lead

acquisition of new lab equipment as needed including assessing requirements and developing

proposals.

Specialized Knowledge & Skills:

• Knowledge of statistical design of experiments, as well as data analysis using JMP or other

statistical package is highly preferred

• Strong desire to learn multiple new techniques and willingness to provide support on R&D

projects is required

• Significant attention to detail and accuracy in developing and following protocols
• Ability to be highly productive in a fluid, fast-paced and teamwork environment

Requirements:

Educational Requirements:

• Degree in chemical engineering, biology, biochemistry, chemistry, biotechnology, and related

fields, with of 4-6 years of relevant experience for BS or 2-4 years of relevant experience for MS.

Experience:

• Technical proficiency and experience with cell line growth optimization and production of

biological products using bioreactors is required

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