Notch is an early-stage biotech company, working to maximize the benefit of cell therapies through a proprietary T cell-production platform which combines sophisticated product design with commercial-compatible processes to enhance patient outcomes. Notch’s iPSC-based technology platform allows for precision control of notch signaling, which removes several critical limiting factors in the development of cell therapies, delivering the ability to design and manufacture a uniform and unlimited supply of therapeutic T cells. www.notchtx.com.

Role Summary

We are seeking a highly motivated Scientist I in the Protein & Cell Engineering group. You will play a pivotal role in supporting lead optimization efforts to drive our oncology pipeline. You will leverage your expertise in vector biology to design, construct, and evaluate molecules that will regulate cell function and phenotype. Additionally, you will apply your knowledge in protein engineering to evaluate and troubleshoot molecular designs. You will work closely with cross-functional groups to ensure seamless integration of molecular biology efforts within the broader development pipeline. Direct experience in molecular biology, understanding of protein structure, and the ability to independently design and execute complex cell engineering experiments are essential.

Key responsibilities:

• Design, optimize, construct, and characterize CARs and TCRs in Primary T-cells
• Design and execute experiments to evaluate and/or troubleshoot molecular designs
• Provide strategic input and direction towards lead optimization efforts

• Interact with scientists within protein & cell engineering and across functional groups to support evaluation of functional payloads in engineered immune cells

• Stay up to date with the latest advancements in molecular biology and protein engineering, and apply this knowledge to enhance project outcomes

• Carry out CRISPR gene editing and lentiviral transduction protocols
• Maintain project timelines and report progress regularly to key stakeholders
• Maintain excellent records of experiments in lab notebooks in a timely manner
• Present data at group and company meetings and externally as required

Role Requirements and Qualifications

• PhD in molecular biology, cell biology, bioengineering, chemical engineering or a closely related discipline with 2+ years of postgraduate work experience in a biotech or industry setting or master’s degree with 10 – 12 years relevant experience.
• Deep experience with construct design, codon optimization and synthesis, and molecular cloning techniques
• Experience with molecular biology software, protein modeling and visualization tools
• Extensive knowledge of protein engineering methods and theory
• Working knowledge of T-cell culture, activation/expansion, and functional assays
• Knowledge of analytical/sorting flow cytometry protocols
• Ability to effectively prioritize, plan, and execute next steps based on experimental results in a fast-paced research environment.
• Strong organizational, record-keeping and communication skills, both verbal and written

Salary Range: $113,000-$135,000

Benefits:

• Paid Vacation and Sick time
• Hybrid Work Framework
• Healthcare plans
• 401k/RRSP plan
• Commuting Financial Assistance

• Home Office WIFI Support
• Employee assistance programs (EAPs)
• Internal learning & development opportunities

Notch Therapeutics Inc. is an equal opportunity employer. All qualified applications will receive consideration for employment without regard to race, age, gender identity, sexual orientation, color, religion, sex, marital status, national origin, protected veteran status, disability status, or any other status protected by federal, provincial or local law.

Requests for accommodation can be made at any stage of the recruitment process providing the applicant has met the Bona-fide requirements for the open position. Applicants need to make their requirements known when contacted.

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