TScan Therapeutics is a clinical-stage biotech seeking to revolutionize life-changing therapeutics for patients by identifying novel T cells and epitopes. We are looking for an experienced researcher to join our team as Principal Research Associate/Associate Scientist in the Molecular Assembly team, supporting our novel target identification and validation workflow in house. The ideal candidate should have relevant experience in cloning techniques and enjoy a fast-paced, collaborative, and vibrant culture. A team player with a sense of urgency will thrive in this role.

Responsibilities:

1. Collaborate with other scientists to design and build various constructs and vectors in support of target/TCR discovery efforts.
2. Assemble large libraries of peptides, TCRs, etc. using specialized cloning protocols.
3. Perform medium- to high-throughput cloning experiments to support discovery efforts in target identification and validation.
4. Analyze and interpret cloning and screening data (e.g., sequencing, functional assays) to guide construct design and optimization.
5. Troubleshoot complex cloning and library construction challenges and propose scalable solutions.
6. Lead group efforts towards technology development and improvement.
7. Implement and optimize high-throughput workflows, including automation where applicable.
8. Train co-workers on molecular cloning techniques.
9. Maintain accurate and well-documented experimental records (e.g., ELN) to ensure data integrity and reproducibility.

Requirements:

1. PhD with 0-2+ years of industry experience; Master’s degree with 5-7+ years of relevant lab experience, preferably in the biopharmaceutical or biotechnology industry.
2. Hands-on experience in a variety of molecular cloning techniques, including Gibson Assembly, Golden Gate Assembly, Gateway recombination, etc.; experience constructing large-scale libraries is desirable.
3. Highly organized with very strong attention to detail.
4. Demonstrated ability to manage multiple projects and meet deadlines in a fast-paced environment.
5. Ability to work both independently and collaboratively and adapt quickly to changing priorities.
6. Scientific creativity, critical thinking, and problem-solving skills.
7. Excellent written and verbal communication skills, with the ability to document experiments in an organized and timely fashion and to present scientific data to coworkers.
8. Familiarity with sequence analysis tools, NGS, and basic bioinformatics workflows preferred.
9. Knowledge of immunology concepts, especially TCR biology and antigen recognition, is preferred.

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