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Job Summary

Postdoctoral position available to study mechanisms of response to immune checkpoint inhibitors in kidney cancer.

Immunotherapy with immune checkpoint inhibitors (e.g. anti-PD-1/PD-L1 agents) has demonstrated clinical efficacy in metastatic renal cell carcinoma (mRCC). Unfortunately, only a subset of mRCC patients responds to these agents. To guide further clinical development of immune checkpoint inhibitors in kidney cancer, we aim to 1) develop and validate tissue-based predictors of drug response using both genomics approaches and in situ analyses; 2) understand the mechanism of action of PD-1/PD-L1 blockade to facilitate the development of highly active combination regimens.

Qualifications

Requirements: We are seeking a highly motivated applicant with an M.D. or M.D./Ph.D. with formal training in Anatomic Pathology (at least 1 year in residency program) and laboratory experience in pathology and/or molecular biology. Background in bioinformatics/computational biology is desirable. Excellent written and oral communication skills are required. The candidate must be willing to commit to the position for at least two years.

If interested, please send a cover letter, CV and three references to:

Sabina Signoretti M.D.

Department of Pathology

Brigham and Women's Hospital

Thorn Building 504A

75 Francis Street

Boston, MA 02115

617-525-7437 (phone)

ssignoretti@bwh.harvard.edu

Additional Job Details (if Applicable)

Remote Type

Onsite

Work Location

75 Francis Street

EEO Statement

2200 The Brigham and Women's Hospital, Inc. is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Veteran’s Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact Human Resources at (857)-282-7642.

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