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Exciting Postdoctoral Opportunity: Join our dynamic laboratory led by Tan Ince. MD, PhD at Cornell University Ince, Tan (cornell.edu).

The position is funded through a new RO1 from NCI, extending until 2028.

Responsibilities

The primary responsibility will include deconstructing the cellular components of a tumor, selectively expanding matched normal, tumor, and stromal cells from the same solid tumor sample as reversible 2D/organoid cultures, and recombine and characterize them using molecular and cellular biology tools as described in Ince et al., Nat Commun. 2015 Jun 17;6:7419. PMID: 26080861.

Qualifications

Candidates who received a recent PhD. or M.D./Ph.D. degree in the last several years are preferred. Recent Ph.D. in cancer biology, molecular and cell biology, biochemistry, oncology, or a related field. Experience in mammalian cell culture is required. The candidates should have lab experience in molecular and cellular biology techniques.

Project Narrative

Over the past 15 years, our lab has successfully established and distributed over 60 cell lines to researchers in 15+ countries. These cell lines have been deposited in reputable repositories such as ATCC, ECACC, and NCI Patient-Derived Models Repository (https://pdmr.cancer.gov/). The ongoing study builds upon this foundation, aiming to develop defined reagents for selectively expanding matched normal, tumor, and stromal cells from the same solid tumor sample as reversible 2D/organoid cultures. Our ultimate goal is to deconstruct the cellular components of a tumor, expand them separately, and recombine them in a controlled experimental system. This innovative approach serves as both a disease model and a personalized oncology tool. Simultaneously, we are advancing a liquid suspension culture method for various leukemia and lymphoma subtypes, with a manuscript currently in preparation.

Joining our lab offers the opportunity to learn cutting-edge cell culture fundamentals, skills, and methods. Successful candidates may contribute to establishing new tumor models that will be utilized and valued by researchers globally.

For more information, please see the links below:

1) Characterization of twenty-five ovarian tumour cell lines that phenocopy primary tumours - PubMed ;

2) Defined, serum-free conditions for in vitro culture of primary human T-ALL blasts - PubMed ;

3) Transformation of different human breast epithelial cell types leads to distinct tumor phenotypes

4) Media Search (usbio.net)

5) Tan A. Ince, MD, PhD - Fighting Cancer by Keeping Cancer Cells Alive • scientia.global

6) New accessions coming soon to the European Collection of Authenticated Cell Cultures - The UKBRCN

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